@article{Ahn:2021:10.1186/s13075-021-02467-1,
author = {Ahn, SS and Yoon, T and Park, Y-B and Prendecki, M and Bhangal, G and McAdoo, SP and Lee, S-W},
doi = {10.1186/s13075-021-02467-1},
journal = {Arthritis Research and Therapy},
pages = {1--12},
title = {Serum chitinase-3-like 1 protein is a useful biomarker to assess disease activity in ANCA-associated vasculitis: an observational study},
url = {http://dx.doi.org/10.1186/s13075-021-02467-1},
volume = {23},
year = {2021}
}

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TY  - JOUR
AB  - BackgroundTo investigate whether serum chitinase-3-like 1 protein (YKL-40) is associated with disease activity in anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV).MethodsELISA was performed in serum samples from AAV patients who were enrolled in our prospective observational cohort to estimate levels of YKL-40. Birmingham vasculitis activity score (BVAS) (version 3), five factor score (FFS), and short form-36 (SF-36), as well as clinical and laboratory data were collected. Kidney expression of YKL-40 was assessed by immunohistochemical staining using renal biopsy tissues from ANCA-associated glomerulonephritis patients (AAGN). Severe AAV and FFS were defined as BVAS ≥ 12 and FFS ≥ 2, and the correlations between laboratory variables, BVAS, FFS, and SF-36 score were assessed using linear regression analysis. The optimal cut-off of serum YKL-40 for severe AAV and high FFS was calculated using the receiver operator characteristic curve analysis.ResultsOf the included 60 patients, 32 (53.3%), 17 (28.3%), and 11 (18.3%) were classified as microscopic polyangiitis, granulomatosis with polyangiitis, and eosinophilic granulomatosis with polyangiitis. The median BVAS and FFS were 7.0 and 1.0, whereas the mean SF-36 physical and mental component scores were 50.5 and 58.3. Serum YKL-40 level was higher in patients with severe AAV and high FFS compared to those without (p = 0.007 and p < 0.001); multivariable linear regression analysis revealed that serum YKL-40 was independently associated with BVAS, FFS, and SF-36 scores. On kidney tissues obtained from AAGN patients, strong cytoplasmic staining of YKL-40 was found in cells present in inflammatory lesions. In addition, AAV patients had higher levels of serum YKL-40 compared to those with systemic lupus erythematosus, rheumatoid arthritis, osteoarthritis, and healthy control. The proportion of patients having severe AAV and high FFS was significantly hig
AU  - Ahn,SS
AU  - Yoon,T
AU  - Park,Y-B
AU  - Prendecki,M
AU  - Bhangal,G
AU  - McAdoo,SP
AU  - Lee,S-W
DO  - 10.1186/s13075-021-02467-1
EP  - 12
PY  - 2021///
SN  - 1478-6354
SP  - 1
TI  - Serum chitinase-3-like 1 protein is a useful biomarker to assess disease activity in ANCA-associated vasculitis: an observational study
T2  - Arthritis Research and Therapy
UR  - http://dx.doi.org/10.1186/s13075-021-02467-1
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000626665900001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://arthritis-research.biomedcentral.com/articles/10.1186/s13075-021-02467-1
UR  - http://hdl.handle.net/10044/1/89308
VL  - 23
ER  - 

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