BibTex format
@article{Yang:2018:10.1002/mp.12832,
author = {Yang, G and Zhuang, X and Khan, H and Haldar, S and Nyktari, E and Li, L and Wage, R and Ye, X and Slabaugh, G and Mohiaddin, R and Wong, T and Keegan, J and Firmin, D},
doi = {10.1002/mp.12832},
journal = {Med Phys},
pages = {1562--1576},
title = {Fully automatic segmentation and objective assessment of atrial scars for long-standing persistent atrial fibrillation patients using late gadolinium-enhanced MRI.},
url = {http://dx.doi.org/10.1002/mp.12832},
volume = {45},
year = {2018}
}
RIS format (EndNote, RefMan)
TY - JOUR
AB - PURPOSE: Atrial fibrillation (AF) is the most common heart rhythm disorder and causes considerable morbidity and mortality, resulting in a large public health burden that is increasing as the population ages. It is associated with atrial fibrosis, the amount and distribution of which can be used to stratify patients and to guide subsequent electrophysiology ablation treatment. Atrial fibrosis may be assessed noninvasively using late gadolinium-enhanced (LGE) magnetic resonance imaging (MRI) where scar tissue is visualized as a region of signal enhancement. However, manual segmentation of the heart chambers and of the atrial scar tissue is time consuming and subject to interoperator variability, particularly as image quality in AF is often poor. In this study, we propose a novel fully automatic pipeline to achieve accurate and objective segmentation of the heart (from MRI Roadmap data) and of scar tissue within the heart (from LGE MRI data) acquired in patients with AF. METHODS: Our fully automatic pipeline uniquely combines: (a) a multiatlas-based whole heart segmentation (MA-WHS) to determine the cardiac anatomy from an MRI Roadmap acquisition which is then mapped to LGE MRI, and (b) a super-pixel and supervised learning based approach to delineate the distribution and extent of atrial scarring in LGE MRI. We compared the accuracy of the automatic analysis to manual ground truth segmentations in 37 patients with persistent long-standing AF. RESULTS: Both our MA-WHS and atrial scarring segmentations showed accurate delineations of cardiac anatomy (mean Dice = 89%) and atrial scarring (mean Dice = 79%), respectively, compared to the established ground truth from manual segmentation. In addition, compared to the ground truth, we obtained 88% segmentation accuracy, with 90% sensitivity and 79% specificity. Receiver operating characteristic analysis achieved an average area under the curve of 0.91. CONCLUSION: Compared with previously studied methods with manual interve
AU - Yang,G
AU - Zhuang,X
AU - Khan,H
AU - Haldar,S
AU - Nyktari,E
AU - Li,L
AU - Wage,R
AU - Ye,X
AU - Slabaugh,G
AU - Mohiaddin,R
AU - Wong,T
AU - Keegan,J
AU - Firmin,D
DO - 10.1002/mp.12832
EP - 1576
PY - 2018///
SP - 1562
TI - Fully automatic segmentation and objective assessment of atrial scars for long-standing persistent atrial fibrillation patients using late gadolinium-enhanced MRI.
T2 - Med Phys
UR - http://dx.doi.org/10.1002/mp.12832
UR - https://www.ncbi.nlm.nih.gov/pubmed/29480931
UR - http://hdl.handle.net/10044/1/57604
VL - 45
ER -
