In this section
@article{Kench:2023:10.1021/acs.bioconjchem.3c00114,
author = {Kench, T and Rakers, V and Bouzada, D and Gomez-Gonzalez, J and Robinson, J and Kuimova, MK and Lopez, MV and Vazquez, ME and Vilar, R},
doi = {10.1021/acs.bioconjchem.3c00114},
journal = {Bioconjugate Chemistry},
pages = {911--921},
title = {Dimeric metal-salphen complexes which target multimeric G-quadruplex DNA},
url = {http://dx.doi.org/10.1021/acs.bioconjchem.3c00114},
volume = {34},
year = {2023}
}
TY - JOUR
AB - G-Quadruplex DNA structures have attracted increasing attention due to their biological roles and potential as targets for the development of new drugs. While most guanine-rich sequences in the genome have the potential to form monomeric G-quadruplexes, certain sequences have enough guanine-tracks to give rise to multimeric quadruplexes. One of these sequences is the human telomere where tandem repeats of TTAGGG can lead to the formation of two or more adjacent G-quadruplexes. Herein we report on the modular synthesis via click chemistry of dimeric metal-salphen complexes (with NiII and PtII) bridged by either polyether or peptide linkers. We show by circular dichroism (CD) spectroscopy that they generally have higher selectivity for dimeric vs monomeric G-quadruplexes. The emissive properties of the PtII-salphen dimeric complexes have been used to study their interactions with monomeric and dimeric G-quadruplexes in vitro as well as to study their cellular uptake and localization.
AU - Kench,T
AU - Rakers,V
AU - Bouzada,D
AU - Gomez-Gonzalez,J
AU - Robinson,J
AU - Kuimova,MK
AU - Lopez,MV
AU - Vazquez,ME
AU - Vilar,R
DO - 10.1021/acs.bioconjchem.3c00114
EP - 921
PY - 2023///
SN - 1043-1802
SP - 911
TI - Dimeric metal-salphen complexes which target multimeric G-quadruplex DNA
T2 - Bioconjugate Chemistry
UR - http://dx.doi.org/10.1021/acs.bioconjchem.3c00114
UR - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000984948100001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=a2bf6146997ec60c407a63945d4e92bb
UR - https://pubs.acs.org/doi/10.1021/acs.bioconjchem.3c00114
UR - http://hdl.handle.net/10044/1/113430
VL - 34
ER -