In this section
Some of the covers featuring our work are shown below:
Wilton-Ely J, 2006, Dinuclear ruthenium and osmium compounds with metal-metal bonds, Comprehensive Organometallic Chemistry III, Editor(s): Crabtree, Mingos, Elsevier, Pages:647-716, ISBN:978-0080445908
@article{Perry:2020:10.1021/acs.inorgchem.0c01318,
author = {Perry, H and Yoon, I and Chabloz, N and Molisso, S and Stasiuk, G and Botnar, R and Wilton-Ely, J},
doi = {10.1021/acs.inorgchem.0c01318},
journal = {Inorganic Chemistry},
pages = {10813--10823},
title = {Metallostar assemblies based on dithiocarbamates for use as MRI contrast agents},
url = {http://dx.doi.org/10.1021/acs.inorgchem.0c01318},
volume = {59},
year = {2020}
}
TY - JOUR
AB - Two different octadentate gadolinium chelates based on DO3A and DOTAGA chelates (hydration number q = 1) have been used to prepare a series of bi-, tri-, and tetrametallic d–f mixed-metal complexes. The piperazine-based dithiocarbamate linker ensures that rotation of the gadolinium chelates is restricted, leading to enhanced relaxivity (r1) values, which increase with the overall mass and number of gadolinium units. The r1 value (at 10 MHz, 25 °C) per gadolinium unit rises from 5.0 mM–1 s–1 for the Gd-DO3A-NH2 monogadolinium chelate to 9.2 mM–1 s–1 in a trigadolinium complex with a ruthenium(III) core. Using a 1.5 T clinical scanner operating at 63.87 MHz (25 °C), an 86% increase in the relaxivity per gadolinium unit is observed for this multimetallic compound compared to clinically approved Dotarem. The gadolinium complexes based on the DOTAGA chelate also performed well at 63.87 MHz, with a relaxivity value of 9.5 mM–1 s–1 per gadolinium unit being observed for the trigadolinium d–f mixed-metal complex with a ruthenium(III) core. The versatility of dithiocarbamate coordination chemistry thus provides access to a wide range of d–f hybrids with potential for use as high-performance MRI contrast agents.
AU - Perry,H
AU - Yoon,I
AU - Chabloz,N
AU - Molisso,S
AU - Stasiuk,G
AU - Botnar,R
AU - Wilton-Ely,J
DO - 10.1021/acs.inorgchem.0c01318
EP - 10823
PY - 2020///
SN - 0020-1669
SP - 10813
TI - Metallostar assemblies based on dithiocarbamates for use as MRI contrast agents
T2 - Inorganic Chemistry
UR - http://dx.doi.org/10.1021/acs.inorgchem.0c01318
UR - https://pubs.acs.org/doi/10.1021/acs.inorgchem.0c01318
UR - http://hdl.handle.net/10044/1/81233
VL - 59
ER -