In this section
@article{Elsherif:2018:10.1021/acsnano.8b00829,
author = {Elsherif, M and Hassan, MU and Yetisen, AK and Butt, H},
doi = {10.1021/acsnano.8b00829},
journal = {ACS Nano},
pages = {5452--5462},
title = {Wearable contact lens biosensors for continuous glucose monitoring using smartphones},
url = {http://dx.doi.org/10.1021/acsnano.8b00829},
volume = {12},
year = {2018}
}
TY - JOUR
AB - Low-cost, robust, and reusable continuous glucose monitoring systems that can provide quantitative measurements at point-of-care settings is an unmet medical need. Optical glucose sensors require complex and time-consuming fabrication processes, and their readouts are not practical for quantitative analyses. Here, a wearable contact lens optical sensor was created for the continuous quantification of glucose at physiological conditions, simplifying the fabrication process and facilitating smartphone readouts. A photonic microstructure having a periodicity of 1.6 μm was printed on a glucose-selective hydrogel film functionalized with phenylboronic acid. Upon binding with glucose, the microstructure volume swelled, which modulated the periodicity constant. The resulting change in the Bragg diffraction modulated the space between zero- and first-order spots. A correlation was established between the periodicity constant and glucose concentration within 0–50 mM. The sensitivity of the sensor was 12 nm mM–1, and the saturation response time was less than 30 min. The sensor was integrated with commercial contact lenses and utilized for continuous glucose monitoring using smartphone camera readouts. The reflected power of the first-order diffraction was measured via a smartphone application and correlated to the glucose concentrations. A short response time of 3 s and a saturation time of 4 min was achieved in the continuous monitoring mode. Glucose-sensitive photonic microstructures may have applications in point-of-care continuous monitoring devices and diagnostics at home settings.
AU - Elsherif,M
AU - Hassan,MU
AU - Yetisen,AK
AU - Butt,H
DO - 10.1021/acsnano.8b00829
EP - 5462
PY - 2018///
SN - 1936-0851
SP - 5452
TI - Wearable contact lens biosensors for continuous glucose monitoring using smartphones
T2 - ACS Nano
UR - http://dx.doi.org/10.1021/acsnano.8b00829
UR - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000436910200041&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR - https://pubs.acs.org/doi/10.1021/acsnano.8b00829
UR - http://hdl.handle.net/10044/1/96379
VL - 12
ER -