@article{Dou:2017:10.1039/c7ra06965k,
author = {Dou, Q and Hu, D and Gao, H and Zhang, Y and Yetisen, AK and Butt, H and Wang, J and Nie, G and Dai, Q},
doi = {10.1039/c7ra06965k},
journal = {RSC Advances: an international journal to further the chemical sciences},
pages = {41384--41390},
title = {High performance boronic acid-containing hydrogel for biocompatible continuous glucose monitoring},
url = {http://dx.doi.org/10.1039/c7ra06965k},
volume = {7},
year = {2017}
}

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TY  - JOUR
AB  - Rapid and robust hydrogels are essential in realizing continuous glucose monitoring in diabetes monitoring. However, existing hydrogels are limited in satisfying all of the sensory requirements such as detection range, response time, recoverability and biocompatibility. Here, we have developed a surface-initiated polymerization method to chemically immobilize a nano-boronic acid-hydrogel membrane onto a quartz crystal, then used a quartz crystal microbalance (QCM) to achieve real-time monitoring of glucose. The experimental results show that this hydrogel possesses enhanced binding properties to glucose under physiological conditions (pH 7.0–7.5) and blood glucose concentration (BGC) (1.1–33.3 mM). Moreover, our hydrogel displayed a rapid response time (∼100 s) to glucose, high biocompatibility in vivo through an animal model. The hydrogel has a great potential as a sensitive glucose probe for implantable continuous glucose sensors.
AU  - Dou,Q
AU  - Hu,D
AU  - Gao,H
AU  - Zhang,Y
AU  - Yetisen,AK
AU  - Butt,H
AU  - Wang,J
AU  - Nie,G
AU  - Dai,Q
DO  - 10.1039/c7ra06965k
EP  - 41390
PY  - 2017///
SN  - 2046-2069
SP  - 41384
TI  - High performance boronic acid-containing hydrogel for biocompatible continuous glucose monitoring
T2  - RSC Advances: an international journal to further the chemical sciences
UR  - http://dx.doi.org/10.1039/c7ra06965k
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000409147000009&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/96396
VL  - 7
ER  - 

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