In this section
@article{Moreddu:2020:10.1016/j.snb.2020.128183,
author = {Moreddu, R and Wolffsohn, JS and Vigolo, D and Yetisen, AK},
doi = {10.1016/j.snb.2020.128183},
journal = {Sensors and actuators B: Chemical},
title = {Laser-inscribed contact lens sensors for the detection of analytes in the tear fluid},
url = {http://dx.doi.org/10.1016/j.snb.2020.128183},
volume = {317},
year = {2020}
}
TY - JOUR
AB - Tears exhibit compositional variations as a response to ocular and systemic metabolic conditions, and they can therefore be used for the assessment of physiological health. Here, microfluidic contact lenses were developed as wearable platforms for in situ tear pH, glucose, protein, and nitrite ions sensing. The microfluidic system was inscribed in commercial contact lenses by CO2 laser ablation. The microchannel consisted on a central ring with four branches, and biosensors were embedded within microcavities located at the branches ends. The device was tested with artificial tears and colorimetric readouts were performed using a smartphone-MATLAB algorithm based on the nearest neighbor model. Sensors responded within a time range of 15 s, and yielded sensitivities of 12.23 nm/pH unit, 1.4 nm/mmol L−1 of glucose, 0.49 nm/g L−1 of proteins, and 0.03 nm/μmol L−1 of nitrites. Contact lens sensing platforms may provide on-eye tears screening with applications in the monitoring of the ocular health both in clinics and at point-of-care settings.
AU - Moreddu,R
AU - Wolffsohn,JS
AU - Vigolo,D
AU - Yetisen,AK
DO - 10.1016/j.snb.2020.128183
PY - 2020///
SN - 0925-4005
TI - Laser-inscribed contact lens sensors for the detection of analytes in the tear fluid
T2 - Sensors and actuators B: Chemical
UR - http://dx.doi.org/10.1016/j.snb.2020.128183
UR - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000536803500003&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR - https://www.sciencedirect.com/science/article/pii/S0925400520305281?via%3Dihub
VL - 317
ER -