@article{Chen:2020:10.1039/d0lc00446d,
author = {Chen, Y and Zhang, S and Cui, Q and Ni, J and Wang, X and Cheng, X and Alem, H and Tebon, P and Xu, C and Guo, C and Nasiri, R and Moreddu, R and Yetisen, AK and Ahadian, S and Ashammakhi, N and Emaminejad, S and Jucaud, V and Dokmeci, MR and Khademhosseini, A},
doi = {10.1039/d0lc00446d},
journal = {Lab on a Chip: miniaturisation for chemistry, physics, biology, materials science and bioengineering},
pages = {4205--4214},
title = {Microengineered poly(HEMA) hydrogels for wearable contact lens biosensing},
url = {http://dx.doi.org/10.1039/d0lc00446d},
volume = {20},
year = {2020}
}

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TY  - JOUR
AB  - Microchannels in hydrogels play an essential role in enabling a smart contact lens. However, microchannels have rarely been created in commercial hydrogel contact lenses due to their sensitivity to conventional microfabrication techniques. Here, we report the fabrication of microchannels in poly(2-hydroxyethyl methacrylate) (poly(HEMA)) hydrogels that are used in commercial contact lenses with a three-dimensional (3D) printed mold. We investigated the corresponding capillary flow behaviors in these microchannels. We observed different capillary flow regimes in these microchannels, depending on their hydration level. In particular, we found that a peristaltic pressure could reinstate flow in a dehydrated channel, indicating that the motion of eye-blinking may help tears flow in a microchannel-containing contact lens. Colorimetric pH and electrochemical Na+ sensing capabilities were demonstrated in these microchannels. This work paves the way for the development of microengineered poly(HEMA) hydrogels for various biomedical applications such as eye-care and wearable biosensing.
AU  - Chen,Y
AU  - Zhang,S
AU  - Cui,Q
AU  - Ni,J
AU  - Wang,X
AU  - Cheng,X
AU  - Alem,H
AU  - Tebon,P
AU  - Xu,C
AU  - Guo,C
AU  - Nasiri,R
AU  - Moreddu,R
AU  - Yetisen,AK
AU  - Ahadian,S
AU  - Ashammakhi,N
AU  - Emaminejad,S
AU  - Jucaud,V
AU  - Dokmeci,MR
AU  - Khademhosseini,A
DO  - 10.1039/d0lc00446d
EP  - 4214
PY  - 2020///
SN  - 1473-0189
SP  - 4205
TI  - Microengineered poly(HEMA) hydrogels for wearable contact lens biosensing
T2  - Lab on a Chip: miniaturisation for chemistry, physics, biology, materials science and bioengineering
UR  - http://dx.doi.org/10.1039/d0lc00446d
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000588192800007&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://pubs.rsc.org/en/content/articlelanding/2020/LC/D0LC00446D
VL  - 20
ER  - 

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