Imperial College London
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Professor Christl Donnelly CBE FMedSci FRS

Faculty of Medicine, School of Public Health

Visiting Professor
 
 
 
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Contact

 

c.donnelly Website

 
 
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Location

 

School of Public HealthWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Penn:2023:gbe/evad213,
author = {Penn, MJ and Scheidwasser, N and Penn, J and Donnelly, CA and Duchêne, DA and Bhatt, S},
doi = {gbe/evad213},
journal = {Genome Biol Evol},
title = {Leaping through Tree Space: Continuous Phylogenetic Inference for Rooted and Unrooted Trees.},
url = {http://dx.doi.org/10.1093/gbe/evad213},
volume = {15},
year = {2023}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Phylogenetics is now fundamental in life sciences, providing insights into the earliest branches of life and the origins and spread of epidemics. However, finding suitable phylogenies from the vast space of possible trees remains challenging. To address this problem, for the first time, we perform both tree exploration and inference in a continuous space where the computation of gradients is possible. This continuous relaxation allows for major leaps across tree space in both rooted and unrooted trees, and is less susceptible to convergence to local minima. Our approach outperforms the current best methods for inference on unrooted trees and, in simulation, accurately infers the tree and root in ultrametric cases. The approach is effective in cases of empirical data with negligible amounts of data, which we demonstrate on the phylogeny of jawed vertebrates. Indeed, only a few genes with an ultrametric signal were generally sufficient for resolving the major lineages of vertebrates. Optimization is possible via automatic differentiation and our method presents an effective way forward for exploring the most difficult, data-deficient phylogenetic questions.
AU  - Penn,MJ
AU  - Scheidwasser,N
AU  - Penn,J
AU  - Donnelly,CA
AU  - Duchêne,DA
AU  - Bhatt,S
DO  - gbe/evad213
PY  - 2023///
TI  - Leaping through Tree Space: Continuous Phylogenetic Inference for Rooted and Unrooted Trees.
T2  - Genome Biol Evol
UR  - http://dx.doi.org/10.1093/gbe/evad213
UR  - https://www.ncbi.nlm.nih.gov/pubmed/38085949
VL  - 15
ER  -
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