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Project Title: Age, Sex, AD Pathology and Synaptic Proteomic Signatures Supervisors: Dr Johanna Jackson, Dr Yu Ye
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Project Title: Discovering Risk Genes and Pathways in Alzheimer’s Disease: Integrative Enhancer-to-Gene Interactome Mapping of the Cerebral Vasculature Supervisors: Dr Alexi Nott, Professor Michael Johnson, Dr Sarah Marzi
Project Title: Multi-modal Machine Learning for the Prediction and Clinical Stratification of Parkinson’s Disease Supervisors: Dr Cynthia Sandor, Professor Payam Barnaghi, Professor Marina Botto
Project Title: Investigation of Stress-Induced Senescence Associated with Ageing and Neurodegeneration Supervisors: Dr Raffaella Nativio, Professor Jesus Gil
Project Title: What Makes a Neuron Vulnerable to Early Alzheimer’s Disease? Supervisors: Professor Paul Matthews, Dr Eugene Duff, Dr Javier Alegre Abarrategui
Project Title: Investigating the Role of Inducible Proteasome Subunits in Neuronal Models of Tauopathies Supervisors: Dr Yu Ye, Dr Johanna Jackson, Professor Amin Hajitou
Project Title: High Throughput Ultrasound Parameter Space Mapping and Manipulation Tools for Targeted Ultrasound Neuromodulation Supervisors: Dr Sophie Morse, Dr Periklis Pantazis, Dr James Choi
Project title: The Pathological Glial-Neuron Interactions and Tau Pathology in Alzheimer’s Disease Supervisors: Professor Paul Matthews, Dr Javier Alegre Abarrategui
Project Title: Deciphering Epigenetic Regulation of Astrocyte Functional States in Healthy Ageing and in Alzheimer’s Disease Supervisors: Dr Raffaella Nativio, Professor Simone Di Giovanni
Project Title: Enhancing Prediction of the Effects of Genetic Variation on DNA Methylation using Machine Learning Supervisors: Dr Nathan Skene
Project Title: Closed-Loop EEG with Temporal Interference Stimulation Supervisors: Dr Nir Grossman
Project Title: Ultrasound modulation of the brain’s immune cells - a strategy to delay ageing Supervisors: Dr Sophie Morse, Professor Jesus Gil
Project Title: Investigating the Interplay between Circadian Clocks and mTOR Signalling in Microglia and its Disruption in Neurodegeneration Supervisor: Dr Marco Brancaccio
Project Title: Multi-‘omic Characterisation of Vulnerable Synaptic Components in Alzheimer’s Disease Supervisors: Dr Johanna Jackson, Dr Samuel Barnes
Project Title: Epigenomic Profiling in Disease Relevant Cell Types Supervisor: Dr Nathan Skene
Project Title: Elucidating Genetic Regulatory Networks in Alzheimer’s Disease and Drug Repurposing Supervisor: Professor Paul Matthews, Dr Eugene Duff
Project Title: Using focused ultrasound to modulate microglial function in neuroinflammation and Alzheimer’s disease Supervisors: Dr Sophie Morse, Professor Paul Matthews
Project Title: Towards the Early Diagnostic and Identification of New Drug Targets for Parkinson’s Disease by Digital Tracking of Early Non-Motor Symptoms Supervisor: Dr Cynthia Sandor
Project Title: Enabling and generating cell type specific maps of genome regulation using TIP-seq Supervisor: Dr Nathan Skene, Dr Alexi Nott, Dr Maria Weinert
Project Title: Distributed, Multi-Channel Temporal-Interference Platform: Hardware Foundations & Solver Algorithms Supervisors: Dr Tim Constandinou, Dr Nir Grossman
Project Title: Investigating the molecular and cellular mechanisms connecting amyloidosis to circadian disruption Supervisors: Dr Marco Brancaccio, Dr Samuel Barnes
Project Title: Translational Medicine in Alzheimer’s Disease: TSPO Modulation in AD; MINDMAPS 2.0; Computational Drug Discovery in AD Supervisor: Professor Paul Matthews
Project title: How Do TREM2 Gene Variants Enhance Susceptibility to Alzheimer’s Disease? Supervisor: Professor Paul Matthews, Dr Raffaella Nativio, Professor David Owen
Project Title: Multi-omic Characterisation of the Molecular Neuropathology of ABCA7 Variants in Alzheimer’s Disease Supervisor: Professor Paul Matthews, Dr Johanna Jackson, Dr David Owen
Project Title: The role of LRRK2 in microglial senescence in Parkinson’s disease Supervisors: Dr Nurun Fancy, Dr Paul Matthews, Dr Raffaella Nativio, Dr Diego Gomez-Nicola
Project Title: Modelling the therapeutic trajectory of noninvasive deep brain stimulation intervention for Alzheimer’s disease Supervisors: Dr Nir Grossman, Professor Mauricio Barahona, Dr Christopher Butler
Project Title: Driving cell-type specific plasticity with multiplexed temporal interference brain stimulation Supervisor: Dr Sam Barnes
Project Title: The effect of focused ultrasound on astrocytes and its consequences on the glymphatic system Supervisors: Dr Sophie Morse, Dr Andriy Kozlov
Project Title: TBC Supervisors: Dr Nathan Skene, Dr Marina Evangelou
Project Title: Microglial Responses to protein aggregates in Parkinson’s Disease Supervisors: Dr Anna Mallach, Dr Johanna Jackson
Project Title: Non-Invasive Deep-Brain Recording Technologies for Focal, Closed-Loop Neural Monitoring Supervisors: Dr Nir Grossman, Dr Shlomi Haar
Project Title: Investigating the Epigenomic Changes in Vascular and Immune Cells of the Ageing Human Brain Supervisors: Dr Alexi Nott, Dr David Owen
Project Title: Proteomic Signatures of Synaptic Vulnerability and Resilience in Alzheimer’s Disease Supervisor: Dr Samuel Barnes
Project Title: Developing closed-loop control brain stimulation to treat Alzheimer’s disease Supervisor: Dr Nir Grossman
Project Title: Understanding the molecular and structural basis of brain hyperactivity in Alzheimer's Disease and its potential for therapeutic intervention Supervisor: Dr Johanna Jackson, Professor Harry Low
Project Title: Ultrasound modulation of neuronal health and synaptic plasticity to mitigate cognitive decline in ageing Supervisors: Dr Sophie Morse, Dr Samuel Barnes
