PLEASE NOTE:
This seminar will take place in person only and will not be recorded. Registration via Eventbrite is no longer needed for Department Seminars; you can simply turn up. We recommend that you add this event to your calendar to receive reminders.
Title:
Supramolecular (Bio)materials: From fundamentals to advanced healthcare solutions
Abstract:
Supramolecular (bio)materials exhibit highly useful properties that are impossible with traditional materials but crucial for a wide variety of emerging applications in industry or biomedicine. These materials typically employ enthalpy-dominated crosslinking interactions that become more dynamic at elevated temperatures, leading to significant softening.
Herein, we will discuss the development of a supramolecular hydrogel platform exploiting dynamic and multivalent interactions between biopolymers and nanoparticles that are strongly entropically driven, providing alternative temperature dependencies than typical for materials of this type. We will discuss the implications of these crosslinking thermodynamics on the observed mechanical properties, demonstrating that tuning the thermodynamics and kinetics of these crosslinking interactions enable broad modulation of the mechanical properties of these materials, including their shear-dependent viscosities, temperature responsiveness, self-healing, and cargo encapsulation and controlled release. These materials exhibit viscous flow under shear stress (shear-thinning) and rapid recovery of mechanical properties when the applied stress is relaxed (self-healing), affording facile processing though direct injection or spraying approaches, making then well served for applications in industry and biomedicine.
Moreover, the hierarchical construction of these biphasic hydrogels enables innovative approaches to formulation and delivery as a diverse array of compounds over user-defined timeframes ranging from days to months. In one example, we demonstrate that these unique characteristics can be leveraged to generate vaccines exhibiting greatly enhanced magnitude, quality, and durability of immune responses. In another example, we demonstrate that these materials can be leveraged to generate new wildland fire retardant formulations enabling prophylactic treatments of high-risk landscapes for wildfire prevention.
Overall, this talk will illustrate our recent efforts exploiting dynamic and multivalent interactions between polymers and nanoparticles to generate hydrogel materials exhibiting properties not previously observed in biomaterials and affording unique opportunities in industry and biomedicine.
Bio:
Eric A. Appel is an Associate Professor of Materials Science & Engineering at Stanford University. He received his BS in Chemistry and MS in Polymer Science from California Polytechnic State University in San Luis Obispo, CA. Eric performed his MS thesis research with Dr Jim Hedrick and Dr Robert Miller on the synthesis of polymers for drug delivery applications at the IBM Almaden Research Center in San Jose, CA. He then obtained his PhD in Chemistry with Prof. Oren A. Scherman at the University of Cambridge. His PhD research focused on the preparation of dynamic and stimuli-responsive supramolecular polymeric materials. For his PhD work, Eric was the recipient of the Jon Weaver PhD prize from the Royal Society of Chemistry and a Graduate Student Award from the Materials Research Society. Upon graduating from Cambridge, he was awarded a National Research Service Award from the NIBIB and a Wellcome Trust Postdoctoral Fellowship to work with Prof. Robert Langer at MIT on the development of supramolecular biomaterials for applications in tissue engineering and drug delivery.
Eric’s research at Stanford focuses on the development of biomimetic polymeric materials that can be used as tools to better understand fundamental biological processes and to engineer advanced healthcare solutions. His research has led to more than one hundred publications and 35 patents. He has been awarded young faculty awards from the Hellman Foundation, American Diabetes Association, American Cancer Society, and PhRMA Foundation. Eric received the IUPAC Hanwha-TotalEnergies Young Polymer Scientist Award in 2022, the Society for Biomaterials Young Investigator Award in 2023, and the Biomaterials Science Lectureship Award in 2023.