In this section
We use light to develop advanced diagnostic tools, wearable sensors, and microscale robots for studying diseases and enabling minimally invasive treatments.
We use photonics to develop new technologies for medicine and to study the pathophysiology of disease. This includes new and improved diagnostic tools as well as microscale robotic devices for therapeutic applications. We use a variety of optical techniques for this purpose such as fluorescence, Raman and diffuse reflectance spectroscopy, as well as microscopy and interferometry. We develop devices ranging from wearable sensors and fibre-optic probes for minimally invasive diagnostics through to microscale robots for cellular-scale manipulation and therapy.
Our research has a number of potential clinical applications including improved monitoring of clinical therapies and interventions (e.g. in inflammatory bowel disease and malnutrition), early diagnosis of infection, and even margin mapping in tumour resection surgery.
The devices we are developing can potentially provide less invasive and lower cost diagnostics. In turn, this may facilitate patient benefits including earlier diagnosis, earlier identification of relapse (e.g. in therapy response monitoring applications), more widespread deployment and more comfortable patient experiences (e.g. through use of less invasive probes and sensors).
Dr Belal Ahmad
Imperial College Research Fellow
Dr Qian Chen
Clinical Research Fellow
Dr Ahmed Ezzat
Research Postgraduate
Dr Nilanjan Mandal
Research Associate in Optical Sensing for LMICs
Dr Alexander J Thompson
Senior Lecturer in Biomedical Sensing
Mr Zeyu Wang
Research Postgraduate
@inproceedings{Thompson:2014:10.1117/12.2037851,
author = {Thompson, AJ and Tang, T-YD and Herling, TW and Hak, CRC and Mann, S and Knowles, TPJ and Kuimova, MK},
doi = {10.1117/12.2037851},
publisher = {SPIE- Society of Photo-optical Instrumentation Engineers},
title = {Quantitative sensing of microviscosity in protocells and amyloid materials using fluorescence lifetime imaging of molecular rotors},
url = {http://dx.doi.org/10.1117/12.2037851},
year = {2014}
}
TY - CPAPER
AB - Molecular rotors are fluorophores that have a fluorescence quantum yield that depends upon intermolecular rotation. The fluorescence quantum yield, intensity and lifetime of molecular rotors all vary as functions of viscosity, as high viscosities inhibit intermolecular rotation and cause an increase in the non-radiative decay rate. As such, molecular rotors can be used to probe viscosity on microscopic scales. Here, we apply fluorescence lifetime imaging microscopy (FLIM) to measure the fluorescence lifetimes of three different molecular rotors, in order to determine the microscopic viscosity in two model systems with significant biological interest. First, the constituents of a novel protocell – a model of a prebiotic cell – were studied using the molecular rotors BODIPY C10 and kiton red. Second, amyloid formation was investigated using the molecular rotor Cy3. © (2014) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
AU - Thompson,AJ
AU - Tang,T-YD
AU - Herling,TW
AU - Hak,CRC
AU - Mann,S
AU - Knowles,TPJ
AU - Kuimova,MK
DO - 10.1117/12.2037851
PB - SPIE- Society of Photo-optical Instrumentation Engineers
PY - 2014///
SN - 0277-786X
TI - Quantitative sensing of microviscosity in protocells and amyloid materials using fluorescence lifetime imaging of molecular rotors
UR - http://dx.doi.org/10.1117/12.2037851
UR - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000336037200028&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR - http://hdl.handle.net/10044/1/31343
ER -
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