In this section
We use light to develop advanced diagnostic tools, wearable sensors, and microscale robots for studying diseases and enabling minimally invasive treatments.
We use photonics to develop new technologies for medicine and to study the pathophysiology of disease. This includes new and improved diagnostic tools as well as microscale robotic devices for therapeutic applications. We use a variety of optical techniques for this purpose such as fluorescence, Raman and diffuse reflectance spectroscopy, as well as microscopy and interferometry. We develop devices ranging from wearable sensors and fibre-optic probes for minimally invasive diagnostics through to microscale robots for cellular-scale manipulation and therapy.
Our research has a number of potential clinical applications including improved monitoring of clinical therapies and interventions (e.g. in inflammatory bowel disease and malnutrition), early diagnosis of infection, and even margin mapping in tumour resection surgery.
The devices we are developing can potentially provide less invasive and lower cost diagnostics. In turn, this may facilitate patient benefits including earlier diagnosis, earlier identification of relapse (e.g. in therapy response monitoring applications), more widespread deployment and more comfortable patient experiences (e.g. through use of less invasive probes and sensors).
Dr Belal Ahmad
Imperial College Research Fellow
Dr Qian Chen
Clinical Research Fellow
Dr Ahmed Ezzat
Research Postgraduate
Dr Nilanjan Mandal
Research Associate in Optical Sensing for LMICs
Dr Alexander J Thompson
Senior Lecturer in Biomedical Sensing
Mr Zeyu Wang
Research Postgraduate
@inproceedings{Thompson:2016:10.1117/12.2212769,
author = {Thompson, AJ and Koziej, L and Williams, H and Elson, D and Yang, G},
doi = {10.1117/12.2212769},
publisher = {SPIE},
title = {Towards optical fibre based Raman spectroscopy for the detection of surgical site infection},
url = {http://dx.doi.org/10.1117/12.2212769},
year = {2016}
}
TY - CPAPER
AB - Surgical site infections (SSIs) are common post-surgical complications that remain significant clinical problems, as they are associated with substantial mortality and morbidity. As such, there is significant interest in the development of minimally invasive techniques that permit early detection of SSIs. To this end, we are applying a compact, clinically deployable Raman spectrometer coupled to an optical fibre probe to the study of bacteria, with the long term goal of using Raman spectroscopy to detect infection in vivo. Our system comprises a 785 nm laser diode for excitation and a commercial (Ocean Optics, Inc.) Raman spectrometer for detection. Here we discuss the design, optimisation and validation of this system, and describe our first experiences interrogating bacterial cells (Escherichia coli) in vitro. © (2016) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
AU - Thompson,AJ
AU - Koziej,L
AU - Williams,H
AU - Elson,D
AU - Yang,G
DO - 10.1117/12.2212769
PB - SPIE
PY - 2016///
TI - Towards optical fibre based Raman spectroscopy for the detection of surgical site infection
UR - http://dx.doi.org/10.1117/12.2212769
UR - http://hdl.handle.net/10044/1/30911
ER -
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