In this section
We use light to develop advanced diagnostic tools, wearable sensors, and microscale robots for studying diseases and enabling minimally invasive treatments.
We use photonics to develop new technologies for medicine and to study the pathophysiology of disease. This includes new and improved diagnostic tools as well as microscale robotic devices for therapeutic applications. We use a variety of optical techniques for this purpose such as fluorescence, Raman and diffuse reflectance spectroscopy, as well as microscopy and interferometry. We develop devices ranging from wearable sensors and fibre-optic probes for minimally invasive diagnostics through to microscale robots for cellular-scale manipulation and therapy.
Our research has a number of potential clinical applications including improved monitoring of clinical therapies and interventions (e.g. in inflammatory bowel disease and malnutrition), early diagnosis of infection, and even margin mapping in tumour resection surgery.
The devices we are developing can potentially provide less invasive and lower cost diagnostics. In turn, this may facilitate patient benefits including earlier diagnosis, earlier identification of relapse (e.g. in therapy response monitoring applications), more widespread deployment and more comfortable patient experiences (e.g. through use of less invasive probes and sensors).
Dr Belal Ahmad
Imperial College Research Fellow
Dr Qian Chen
Clinical Research Fellow
Dr Ahmed Ezzat
Research Postgraduate
Dr Nilanjan Mandal
Research Associate in Optical Sensing for LMICs
Dr Alexander J Thompson
Senior Lecturer in Biomedical Sensing
Mr Zeyu Wang
Research Postgraduate
@article{Vysniauskas:2018:2050-6120/aabb2c,
author = {Vysniauskas, A and Lopez, Duarte I and Thompson, AJ and Bull, JA and Kuimova, MK},
doi = {2050-6120/aabb2c},
journal = {Methods and Applications in Fluorescence},
title = {Surface functionalisation with viscosity-sensitive BODIPY molecular rotor},
url = {http://dx.doi.org/10.1088/2050-6120/aabb2c},
volume = {6},
year = {2018}
}
TY - JOUR
AB - Surface functionalisation with viscosity sensitive dyes termed ‘molecular rotors’ can potentially open up new opportunities in sensing, for example for non-invasive biological viscosity imaging, in studying the effect of shear stress on lipid membranes and in cells, and in imaging contacts between surfaces upon applied pressure. We have functionalised microscope slides with BODIPY-based molecular rotor capable of viscosity sensing via its fluorescence lifetime. We have optimised functionalisation conditions and prepared the slides with the BODIPY rotor attached directly to the surface of glass slides and through polymer linkers of 5 kDa and 40 kDa in mass. The slides were characterised for their sensitivity to viscosity, and used to measure viscosity of supported lipid bilayers during photooxidation, and of giant unilamellar vesicles lying on the surface of the slide. We conclude that our functionalised slides show promise for a variety of viscosity sensing applications.
AU - Vysniauskas,A
AU - Lopez,Duarte I
AU - Thompson,AJ
AU - Bull,JA
AU - Kuimova,MK
DO - 2050-6120/aabb2c
PY - 2018///
SN - 2050-6120
TI - Surface functionalisation with viscosity-sensitive BODIPY molecular rotor
T2 - Methods and Applications in Fluorescence
UR - http://dx.doi.org/10.1088/2050-6120/aabb2c
UR - http://hdl.handle.net/10044/1/57554
VL - 6
ER -
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