In this section

Mechatronics in Medicine

The MIM Lab develops robotic and mechatronics surgical systems for a variety of procedures.

Head of Group

B415C Bessemer Building
South Kensington Campus

+44 (0)20 7594 7046

What we do

The Mechatronics in Medicine Laboratory develops robotic and mechatronics surgical systems for a variety of procedures including neuro, cardiovascular, orthopaedic surgeries, and colonoscopies. Examples include bio-inspired catheters that can navigate along complex paths within the brain (such as EDEN2020), soft robots to explore endoluminal anatomies (such as the colon), and virtual reality solutions to support surgeons during knee replacement surgeries.

Meet the team

Mr Ayhan Aktas
Casual - Student demonstrator - lower rate

Dr Daniel Bautista Salinas
Research Associate

Dr Kaiwen Chen
Research Associate

Mr Zejian Cui
Research Assistant

Mr Connor Daly
Research Postgraduate

Emeritus Professor Brian L Davies FREng
Emeritus Professor

Mr Zhaoyang Jacopo Hu
Research Postgraduate

Dr Hisham M Iqbal
Research Associate

Mr Alex Ranne
Research Postgraduate

Professor Ferdinando M Rodriguez y Baena
Co-Director of Hamlyn Centre, Professor of Medical Robotics

Dr Jialei Shi
Research Associate

Mr Spyridon Souipas
Casual - Other work

Ms Emilia Zari
Research Postgraduate

Citation

BibTex format

@article{Zhan:2019:10.1080/10717544.2019.1639844,
author = {Zhan, W and Rodriguez, y Baena F and Dini, D},
doi = {10.1080/10717544.2019.1639844},
journal = {Drug Delivery},
pages = {773--781},
title = {Effect of tissue permeability and drug diffusion anisotropy on convection-enhanced delivery},
url = {http://dx.doi.org/10.1080/10717544.2019.1639844},
volume = {26},
year = {2019}
}

Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Although convection-enhanced delivery (CED) can successfully facilitate a bypass of the blood brain barrier, its treatment efficacy remains highly limited in clinic. This can be partially attributed to the brain anisotropic characteristics that lead to the difficulties in controlling the drug spatial distribution. Here, the responses of six different drugs to the tissue anisotropy are examined through a parametric study performed using a multiphysics model, which considers interstitial fluid flow, tissue deformation and interlinked drug transport processes in CED. The delivery outcomes are evaluated in terms of the penetration depth and delivery volume for effective therapy. Simulation results demonstrate that the effective penetration depth in a given direction can be improved with the increase of the corresponding component of anisotropic characteristics. The anisotropic tissue permeability could only reshape the drug distribution in space but has limited contribution to the total effective delivery volume. On the other hand, drugs respond in different ways to the anisotropic diffusivity. The large delivery volumes of fluorouracil, carmustine, cisplatin and doxorubicin could be achieved in relatively isotropic tissue, while paclitaxel and methotrexate are able to cover enlarged regions into anisotropic tissues. Results obtained from this study serve as a guide for the design of CED treatments.
AU  - Zhan,W
AU  - Rodriguez,y Baena F
AU  - Dini,D
DO  - 10.1080/10717544.2019.1639844
EP  - 781
PY  - 2019///
SN  - 1071-7544
SP  - 773
TI  - Effect of tissue permeability and drug diffusion anisotropy on convection-enhanced delivery
T2  - Drug Delivery
UR  - http://dx.doi.org/10.1080/10717544.2019.1639844
UR  - https://www.tandfonline.com/doi/full/10.1080/10717544.2019.1639844
UR  - http://hdl.handle.net/10044/1/72220
VL  - 26
ER  -