In this section

Mechatronics in Medicine

The MIM Lab develops robotic and mechatronics surgical systems for a variety of procedures.

Head of Group

B415C Bessemer Building
South Kensington Campus

+44 (0)20 7594 7046

What we do

The Mechatronics in Medicine Laboratory develops robotic and mechatronics surgical systems for a variety of procedures including neuro, cardiovascular, orthopaedic surgeries, and colonoscopies. Examples include bio-inspired catheters that can navigate along complex paths within the brain (such as EDEN2020), soft robots to explore endoluminal anatomies (such as the colon), and virtual reality solutions to support surgeons during knee replacement surgeries.

Meet the team

Mr Ayhan Aktas
Casual - Student demonstrator - lower rate

Dr Daniel Bautista Salinas
Research Associate

Dr Kaiwen Chen
Research Associate

Mr Zejian Cui
Research Assistant

Mr Connor Daly
Research Postgraduate

Emeritus Professor Brian L Davies FREng
Emeritus Professor

Mr Zhaoyang Jacopo Hu
Research Postgraduate

Dr Hisham M Iqbal
Research Associate

Mr Alex Ranne
Research Postgraduate

Professor Ferdinando M Rodriguez y Baena
Co-Director of Hamlyn Centre, Professor of Medical Robotics

Dr Jialei Shi
Research Associate

Mr Spyridon Souipas
Casual - Other work

Ms Emilia Zari
Research Postgraduate

Citation

BibTex format

@article{Jamal:2022:10.3390/ijms23063139,
author = {Jamal, A and Yuan, T and Galvan, S and Castellano, A and Riva, M and Secoli, R and Falini, A and Bello, L and Rodriguez, y Baena F and Dini, D},
doi = {10.3390/ijms23063139},
journal = {International Journal of Molecular Sciences},
pages = {3139--3139},
title = {Insights into infusion-based targeted drug delivery in brain: perspectives, challenges and opportunities},
url = {http://dx.doi.org/10.3390/ijms23063139},
volume = {23},
year = {2022}
}

Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Targeted drug delivery in the brain is instrumental in the treatment of lethal brain diseases, such as glioblastoma multiforme, the most aggressive primary central nervous system tumour in adults. Infusion-based drug delivery techniques, which directly administer to the tissue for local treatment, as in convection-enhanced delivery (CED), provide an important opportunity; however, poor understanding of the pressure-driven drug transport mechanisms in the brain has hindered its ultimate success in clinical applications. In this review, we focus on the biomechanical and biochemical aspects of infusion-based targeted drug delivery in the brain and look into the underlying molecular level mechanisms. We discuss recent advances and challenges in the complementary field of medical robotics and its use in targeted drug delivery in the brain. A critical overview of current research in these areas and their clinical implications is provided. This review delivers new ideas and perspectives for further studies of targeted drug delivery in the brain.
AU  - Jamal,A
AU  - Yuan,T
AU  - Galvan,S
AU  - Castellano,A
AU  - Riva,M
AU  - Secoli,R
AU  - Falini,A
AU  - Bello,L
AU  - Rodriguez,y Baena F
AU  - Dini,D
DO  - 10.3390/ijms23063139
EP  - 3139
PY  - 2022///
SN  - 1422-0067
SP  - 3139
TI  - Insights into infusion-based targeted drug delivery in brain: perspectives, challenges and opportunities
T2  - International Journal of Molecular Sciences
UR  - http://dx.doi.org/10.3390/ijms23063139
UR  - https://www.mdpi.com/1422-0067/23/6/3139
UR  - http://hdl.handle.net/10044/1/95828
VL  - 23
ER  -