In this section
The Micro-Nano Innovation Lab ("mini lab") investigates multidisciplinary approaches to develop new intelligent sensing and robotic strategies in micro/nano scales.
The Micro-Nano Innovation Lab ("mini lab") investigates multidisciplinary approaches to develop new intelligent sensing and robotic strategies in micro/nano scales. We study nanotechnology, light-matter interactions, micro-particle dynamics, microscale fluid dynamics, and bioengineering to reach our goal. The research involves the design and manufacture of micro/nano systems for diagnostics (e.g. infections, cancer, neurodegenerative diseases) and microscopic therapies/surgeries (e.g. localised drug delivery, novel minimally invasive procedures).
Timely identification of illnesses, less intrusive interventions, and precise/personalised treatments in challenging areas within our bodies, like narrow blood vessels, are essential technologies for improved healthcare management. The foundation for empowering these technologies lies in the development of devices capable of sensitively detecting disruptions in microenvironments that impact normal physiology and of precisely addressing these issues via targeted drug delivery, surgery, etc. at the cellular and molecular levels (micro/nano scales). Understanding the pathophysiology and engineering of the designs and functionalities of such devices accordingly is, thus, vital to enhancing current medical technology. Also, this has the potential to drive the development of advanced medical micro-robots with integrated sensing and therapeutic capabilities, offering new opportunities for future advancements in healthcare.
Early detection of diseases followed by minimally invasive, targeted and personalised therapy can have evident advantages for patients in terms of prognosis, health management, and economic implications. First, it can reduce excessive physical and biochemical alterations to the microenvironments, e.g., scarring after resection, antimicrobial resistance after antibiotics administration, etc., offering a better prognosis with fewer side effects. Micro/nanodevices can also be engineered to be implantable, enabling long-term health monitoring and treatment. Finally, the localised and precise manner of the technology allows efficient planning of the optimal procedures and accurate dosage, resulting in reduced cost.
Mr Seungyeop Kang
Research Postgraduate
Dr Jang Ah Kim
Lecturer
@inproceedings{Kim:2012:10.1007/s12010-012-9693-9,
author = {Kim, J and Kasture, M and Hwang, T and Kulkarni, A and Amin, R and Park, S and Kim, T and Gosavi, S},
doi = {10.1007/s12010-012-9693-9},
pages = {1069--1075},
title = {Graphene-based waveguides: novel method for detecting biological activity.},
url = {http://dx.doi.org/10.1007/s12010-012-9693-9},
year = {2012}
}
TY - CPAPER
AB - We demonstrate the fabrication of a biosensor based on graphene coupled with polydimethylsiloxane (PDMS) waveguide. Biosensors work on the principle of local evanescent graphene-coupled wave sensor. It is observed that the evanescent field shifts in the presence of chemical or biological species as evanescent waves are extremely sensitive to a change in refractive index. This method helps to monitor the target analyte by attaching the selective receptor molecules to the surface of the PDMS optical waveguide resulting in its optical intensity distribution shift. We monitor the electrical properties of graphene in the dark and under illumination of PDMS waveguide. The changes in photocurrent through the graphene film were monitored for blue, green, and red light. We observed that the fabricated graphene-coupled PDMS optical waveguide sensor is sensitive to visible light for the used bioanalytes.
AU - Kim,J
AU - Kasture,M
AU - Hwang,T
AU - Kulkarni,A
AU - Amin,R
AU - Park,S
AU - Kim,T
AU - Gosavi,S
DO - 10.1007/s12010-012-9693-9
EP - 1075
PY - 2012///
SP - 1069
TI - Graphene-based waveguides: novel method for detecting biological activity.
UR - http://dx.doi.org/10.1007/s12010-012-9693-9
UR - https://www.ncbi.nlm.nih.gov/pubmed/22569782
ER -
The Hamlyn Centre
Bessemer Building
South Kensington Campus
Imperial College
London, SW7 2AZ
Map location
