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The Micro-Nano Innovation Lab ("mini lab") @Hamlyn investigates and utilises light-matter interactions to develop new intelligent sensing and robotic strategies in micro/nano scales.
The Micro-Nano Innovation Lab ("mini lab") @Hamlyn investigates and utilises light-matter interactions to develop new intelligent sensing and robotic strategies in micro/nano scales. The research involves designing and fabricating micro/nanostructures for diagnostics (e.g. infections, cancer, neurodegenerative diseases) and microscopic therapies/surgeries (e.g. localised drug delivery, novel minimally invasive treatment).
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Dr Jang Ah Kim
Lecturer
@article{Kim:2023:10.1117/1.JBO.28.7.075003,
author = {Kim, JA and Hou, Y and Keshavarz, M and Yeatman, E and Thompson, A},
doi = {10.1117/1.JBO.28.7.075003},
journal = {Journal of Biomedical Optics},
pages = {1--15},
title = {Characterization of bacteria swarming effect under plasmonic optical fiber illumination},
url = {http://dx.doi.org/10.1117/1.JBO.28.7.075003},
volume = {28},
year = {2023}
}
TY - JOUR
AB - SignificancePlasmo-thermo-electrophoresis (PTEP) involves using plasmonic microstructures to generate both a large-scale convection current and a near-field attraction force (thermo-electrophoresis). These effects facilitate the collective locomotion (i.e., swarming) of microscale particles in suspension, which can be utilized for numerous applications, such as particle/cell manipulation and targeted drug delivery. However, to date, PTEP for ensemble manipulation has not been well characterized, meaning its potential is yet to be realized.AimOur study aims to provide a characterization of PTEP on the motion and swarming effect of various particles and bacterial cells to allow rational design for bacteria-based microrobots and drug delivery applications.ApproachPlasmonic optical fibers (POFs) were fabricated using two-photon polymerization. The particle motion and swarming behavior near the tips of optical fibers were characterized by image-based particle tracking and analyzing the spatiotemporal concentration variation. These results were further correlated with the shape and surface charge of the particles defined by the zeta potential.ResultsThe PTEP demonstrated a drag force ranging from a few hundred fN to a few tens of pN using the POFs. Furthermore, bacteria with the greater (negative) zeta potential ( | ζ | > 10 mV) and smoother shape (e.g., Klebsiella pneumoniae and Escherichia coli) exhibited the greatest swarming behavior.ConclusionsThe characterization of PTEP-based bacteria swarming behavior investigated in our study can help predict the expected swarming behavior of given particles/bacterial cells. As such, this may aid in realizing the potential of PTEP in the wide-ranging applications highlighted above.
AU - Kim,JA
AU - Hou,Y
AU - Keshavarz,M
AU - Yeatman,E
AU - Thompson,A
DO - 10.1117/1.JBO.28.7.075003
EP - 15
PY - 2023///
SN - 1083-3668
SP - 1
TI - Characterization of bacteria swarming effect under plasmonic optical fiber illumination
T2 - Journal of Biomedical Optics
UR - http://dx.doi.org/10.1117/1.JBO.28.7.075003
UR - https://www.spiedigitallibrary.org/journals/journal-of-biomedical-optics/volume-28/issue-07/075003/Characterization-of-bacteria-swarming-effect-under-plasmonic-optical-fiber-illumination/10.1117/1.JBO.28.7.075003.full
UR - http://hdl.handle.net/10044/1/105332
VL - 28
ER -