Below is an outline of early clinical and preclinical research activities focussed on therapeutics in the field of haematology, involving avademics from the Centre for Haematology. 

Haemato-Oncology

• Multiple Myeloma: First in man clinical development of GADDβ45 inhibitor.
• Pre-clinical development of GCN2 and PBX1 inhibitors
• HTLV-1 adult T cell lymphoma: Clinical development of anti-CCR4 Ab for treatment of pre-malignant ATL
• Clinical and pre-clinical development of iNKT cell-based immunotherapy
• Stem cell transplantation and cellular immunotherapy (point of care CAR-T immunotherapy).

Red cell haematology and Immunohaematology

• Haemoglobinopathies and Thalassaemias: Gene therapy including gene editing
• Hereditary haemolytic anaemias: Novel allosteric glycolytic enzyme modulators
• Immune thrombocytopenia: Novel immunomodulating small molecules.

Thrombosis and Haemostasis

• Discovery and pre-clinical developments of raft of mAbs as novel anti-coagulations