BibTex format
@article{Vieira:2024:10.1038/s41467-024-47929-7,
author = {Vieira, A and Wan, Y and Ryan, Y and Li, HK and Guy, RL and Papangeli, M and Huse, K and Reeves, LC and Soo, VWC and Daniel, R and Harley, A and Broughton, K and Dhami, C and Ganner, M and Mumin, Z and Razaei, M and Rundberg, E and Mammadov, R and Mills, EA and Sgro, V and Mok, KY and Didelot, X and Croucher, NJ and Jauneikaite, E and Lamagni, T and Brown, CS and Coelho, J and Sriskandan, S},
doi = {10.1038/s41467-024-47929-7},
journal = {Nature Communications},
title = {Rapid expansion and international spread of M1UK in the post-pandemic UK upsurge of Streptococcus pyogenes},
url = {http://dx.doi.org/10.1038/s41467-024-47929-7},
volume = {15},
year = {2024}
}
RIS format (EndNote, RefMan)
TY - JOUR
AB - The UK observed a marked increase in scarlet fever and invasive group A streptococcal infection in 2022 with severe outcomes in children and similar trends worldwide. Here we report lineage M1UK to be the dominant source of invasive infections in this upsurge. Compared with ancestral M1global strains, invasive M1UK strains exhibit reduced genomic diversity and fewer mutations in two-component regulator genes covRS. The emergence of M1UK is dated to 2008. Following a bottleneck coinciding with the COVID-19 pandemic, three emergent M1UK clades underwent rapid nationwide expansion, despite lack of detection in previous years. All M1UK isolates thus-far sequenced globally have a phylogenetic origin in the UK, with dispersal of the new clades in Europe. While waning immunity may promote streptococcal epidemics, the genetic features of M1UK point to a fitness advantage in pathogenicity, and a striking ability to persist through population bottlenecks.
AU - Vieira,A
AU - Wan,Y
AU - Ryan,Y
AU - Li,HK
AU - Guy,RL
AU - Papangeli,M
AU - Huse,K
AU - Reeves,LC
AU - Soo,VWC
AU - Daniel,R
AU - Harley,A
AU - Broughton,K
AU - Dhami,C
AU - Ganner,M
AU - Mumin,Z
AU - Razaei,M
AU - Rundberg,E
AU - Mammadov,R
AU - Mills,EA
AU - Sgro,V
AU - Mok,KY
AU - Didelot,X
AU - Croucher,NJ
AU - Jauneikaite,E
AU - Lamagni,T
AU - Brown,CS
AU - Coelho,J
AU - Sriskandan,S
DO - 10.1038/s41467-024-47929-7
PY - 2024///
SN - 2041-1723
TI - Rapid expansion and international spread of M1UK in the post-pandemic UK upsurge of Streptococcus pyogenes
T2 - Nature Communications
UR - http://dx.doi.org/10.1038/s41467-024-47929-7
UR - https://www.nature.com/articles/s41467-024-47929-7
UR - http://hdl.handle.net/10044/1/111130
VL - 15
ER -