In this section
@article{Boily:2024:10.1186/s12916-024-03580-z,
author = {Boily, M-C},
doi = {10.1186/s12916-024-03580-z},
journal = {BMC Medicine},
title = {From conceptualising to modelling structural determinants and interventions in HIV transmission dynamics models: a scoping review and methodological framework for evidence-based analyses},
url = {http://dx.doi.org/10.1186/s12916-024-03580-z},
volume = {22},
year = {2024}
}
TY - JOUR
AB - BackgroundIncluding structural determinants (e.g. criminalisation, stigma, inequitable gender norms) in dynamic HIV transmission models is important to help quantify their population-level impacts and guide implementation of effective interventions that reduce the burden of HIV and inequalities thereof. However, evidence-based modelling of structural determinants is challenging partly due to a limited understanding of their causal pathways and few empirical estimates of their effects on HIV acquisition and transmission.MethodsWe conducted a scoping review of dynamic HIV transmission modelling studies that evaluated the impacts of structural determinants, published up to August 28, 2023, using Ovid Embase and Medline online databases. We appraised studies on how models represented exposure to structural determinants and causal pathways. Building on this, we developed a new methodological framework and recommendations to support the incorporation of structural determinants in transmission dynamics models and their analyses. We discuss the data and analyses that could strengthen the evidence used to inform these models.ResultsWe identified 17 HIV modelling studies that represented structural determinants and/or interventions, including incarceration of people who inject drugs (number of studies [n] = 5), violence against women (n = 3), HIV stigma (n = 1), and housing instability (n = 1), among others (n = 7). Most studies (n = 10) modelled exposures dynamically. Almost half (8/17 studies) represented multiple exposure histories (e.g. current, recent, non-recent exposure). Structural determinants were often assumed to influence HIV indirectly by influencing mediators such as contact patterns, condom use, and antiretroviral therapy use. However, causal pathways’ assumptions were sometimes simple, with few mediators explicitly represented in the model, and largely based on cross-sect
AU - Boily,M-C
DO - 10.1186/s12916-024-03580-z
PY - 2024///
SN - 1741-7015
TI - From conceptualising to modelling structural determinants and interventions in HIV transmission dynamics models: a scoping review and methodological framework for evidence-based analyses
T2 - BMC Medicine
UR - http://dx.doi.org/10.1186/s12916-024-03580-z
UR - https://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-024-03580-z
UR - http://hdl.handle.net/10044/1/114287
VL - 22
ER -
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