BibTex format
@article{Imada:2024:10.1038/s41586-024-07840-z,
author = {Imada, S and Khawaled, S and Shin, H and Meckelmann, SW and Whittaker, CA and Corrêa, RO and Alquati, C and Lu, Y and Tie, G and Pradhan, D and Calibasi-Kocal, G and Nascentes, Melo LM and Allies, G and Rösler, J and Wittenhofer, P and Krystkiewicz, J and Schmitz, OJ and Roper, J and Vinolo, MAR and Ricciardiello, L and Lien, EC and Vander, Heiden MG and Shivdasani, RA and Cheng, C-W and Tasdogan, A and Yilmaz, ÖH},
doi = {10.1038/s41586-024-07840-z},
journal = {Nature},
pages = {895--904},
title = {Short-term post-fast refeeding enhances intestinal stemness via polyamines.},
url = {http://dx.doi.org/10.1038/s41586-024-07840-z},
volume = {633},
year = {2024}
}
RIS format (EndNote, RefMan)
TY - JOUR
AB - For over a century, fasting regimens have improved health, lifespan and tissue regeneration in diverse organisms, including humans1-6. However, how fasting and post-fast refeeding affect adult stem cells and tumour formation has yet to be explored in depth. Here we demonstrate that post-fast refeeding increases intestinal stem cell (ISC) proliferation and tumour formation; post-fast refeeding augments the regenerative capacity of Lgr5+ ISCs, and loss of the tumour suppressor gene Apc in post-fast-refed ISCs leads to a higher tumour incidence in the small intestine and colon than in the fasted or ad libitum-fed states, demonstrating that post-fast refeeding is a distinct state. Mechanistically, we discovered that robust mTORC1 induction in post-fast-refed ISCs increases protein synthesis via polyamine metabolism to drive these changes, as inhibition of mTORC1, polyamine metabolite production or protein synthesis abrogates the regenerative or tumorigenic effects of post-fast refeeding. Given our findings, fast-refeeding cycles must be carefully considered and tested when planning diet-based strategies for regeneration without increasing cancer risk, as post-fast refeeding leads to a burst in stem-cell-driven regeneration and tumorigenicity.
AU - Imada,S
AU - Khawaled,S
AU - Shin,H
AU - Meckelmann,SW
AU - Whittaker,CA
AU - Corrêa,RO
AU - Alquati,C
AU - Lu,Y
AU - Tie,G
AU - Pradhan,D
AU - Calibasi-Kocal,G
AU - Nascentes,Melo LM
AU - Allies,G
AU - Rösler,J
AU - Wittenhofer,P
AU - Krystkiewicz,J
AU - Schmitz,OJ
AU - Roper,J
AU - Vinolo,MAR
AU - Ricciardiello,L
AU - Lien,EC
AU - Vander,Heiden MG
AU - Shivdasani,RA
AU - Cheng,C-W
AU - Tasdogan,A
AU - Yilmaz,ÖH
DO - 10.1038/s41586-024-07840-z
EP - 904
PY - 2024///
SP - 895
TI - Short-term post-fast refeeding enhances intestinal stemness via polyamines.
T2 - Nature
UR - http://dx.doi.org/10.1038/s41586-024-07840-z
UR - https://www.ncbi.nlm.nih.gov/pubmed/39169180
VL - 633
ER -