In this section
@article{Rhodes:2024,
author = {Rhodes, J},
journal = {npj Antimicrobials and Resistance},
title = {Genomic epidemiology of Candida auris introduction and outbreaks in the United Kingdom},
url = {http://hdl.handle.net/10044/1/114369},
year = {2024}
}
TY - JOUR
AB - Candida auris is a globally emerged fungal pathogen causing nosocomial invasive infections. Here, we use cutting-edge genomic approaches to elucidate the temporal and geographic epidemiology of drug-resistant C. auris within the UK. We analysed a representative sample of over 200 isolates from multiple UK hospitals to assess the number and timings of C. auris introductions, and infer subsequent patterns of inter- and intra-hospital transmission of azole drug resistant isolates. We identify at least one introduction from Clade I and two from Clade III into the UK, and observe temporal and geographical evidence for multiple transmission events of antifungal drug resistant isolates between hospitals and identified local within-hospital patient-to-patient transmission events. Our study confirms outbreaks of drug resistant C. auris are linked and that transmission amongst patients occurs, explaining local hospital outbreaks, and demonstrating a need for improved epidemiological surveillance of C. auris to protect patients and healthcare services.
AU - Rhodes,J
PY - 2024///
SN - 2731-8745
TI - Genomic epidemiology of Candida auris introduction and outbreaks in the United Kingdom
T2 - npj Antimicrobials and Resistance
UR - http://hdl.handle.net/10044/1/114369
ER -
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