BibTex format
@article{Churcher:2024:10.1016/s2214-109x(24)00329-2,
author = {Churcher, TS and Stopard, IJ and Hamlet, A and Dee, DP and Sanou, A and Rowland, M and Guelbeogo, MW and Emidi, B and Mosha, JF and Challenger, JD and Denz, A and Glover, A and Charles, GD and Russell, EL and Fitzjohn, R and Winskill, P and Fornadel, C and Mclean, T and Digre, P and Wagman, J and Mosha, F and Cook, J and Akogbéto, MC and Djogbenou, LS and Ranson, H and McCall, P and Manjurano, A and NFalé, S and Protopopoff, N and Accrombessi, M and Ngufor, C and Foster, G and Sherrard-Smith, E},
doi = {10.1016/s2214-109x(24)00329-2},
journal = {The Lancet Global Health},
pages = {e1973--e1983},
title = {The epidemiological benefit of pyrethroid–pyrrole insecticide treated nets against malaria: an individual-based malaria transmission dynamics modelling study},
url = {http://dx.doi.org/10.1016/s2214-109x(24)00329-2},
volume = {12},
year = {2024}
}
RIS format (EndNote, RefMan)
TY - JOUR
AB - BackgroundInsecticide treated nets (ITNs) are the most important malaria prevention tool in Africa but the rise of pyrethroid resistance in mosquitoes is likely impeding control. WHO has recommended a novel pyrethroid–pyrrole ITN following evidence of epidemiological benefit in two cluster-randomised, controlled trials (CRTs). It remains unclear how effective more costly pyrethroid–pyrrole ITNs are compared with other tools, or whether they should be deployed when budgets are limited. We aimed to compare the epidemiological impact and cost-effectiveness of the mass distribution of pyrethroid–pyrrole ITNs relative to other ITNs over 3 years in different African settings.MethodsIn this individual-based malaria transmission dynamics modelling study we characterise the entomological impact of ITNs using data from a systematic review of experimental hut trials from across Africa. This African entomological data was used to inform an individual-based malaria transmission dynamics model, which was validated against CRT results from Benin and Tanzania. The full impact of new ITNs was quantified for trial sites and simulation was used to project impact in different settings which were included within an accessible interface (the Malaria Intervention Tool) to support National Malaria Programmes to explore how vector control tools and budgets could be allocated across regions to avert the most cases.FindingsThe model projects that distributing pyrethroid–pyrrole ITNs averted 65% (95% credible interval 48–74) of cases over 3 years in Tanzania, and 75% (28–93) in Benin. The model indicates that trials might have underestimated the benefits of switching ITNs by 12–16% over 3 years because participants stopped using trial-allocated nets. In moderate endemicity non-trial settings, pyrethroid–pyrrole ITNs are projected to reduce malaria prevalence by 25–60% and switching from pyrethroid-only ITNs is probably highly cost-effective
AU - Churcher,TS
AU - Stopard,IJ
AU - Hamlet,A
AU - Dee,DP
AU - Sanou,A
AU - Rowland,M
AU - Guelbeogo,MW
AU - Emidi,B
AU - Mosha,JF
AU - Challenger,JD
AU - Denz,A
AU - Glover,A
AU - Charles,GD
AU - Russell,EL
AU - Fitzjohn,R
AU - Winskill,P
AU - Fornadel,C
AU - Mclean,T
AU - Digre,P
AU - Wagman,J
AU - Mosha,F
AU - Cook,J
AU - Akogbéto,MC
AU - Djogbenou,LS
AU - Ranson,H
AU - McCall,P
AU - Manjurano,A
AU - NFalé,S
AU - Protopopoff,N
AU - Accrombessi,M
AU - Ngufor,C
AU - Foster,G
AU - Sherrard-Smith,E
DO - 10.1016/s2214-109x(24)00329-2
EP - 1983
PY - 2024///
SN - 2214-109X
SP - 1973
TI - The epidemiological benefit of pyrethroid–pyrrole insecticide treated nets against malaria: an individual-based malaria transmission dynamics modelling study
T2 - The Lancet Global Health
UR - http://dx.doi.org/10.1016/s2214-109x(24)00329-2
UR - http://hdl.handle.net/10044/1/116021
VL - 12
ER -